Introduction

A cataract is an opacification or clouding of the lens. It is the most common cause of blindness worldwide.

Cataracts can affect people of all ages, but they are particularly prevalent in elderly patients. Cataracts are found in 75% of people over 65 years old.1


Anatomy

The lens helps to focus light onto the retina.

There are 3 main anatomical structures of the lens relevant to cataracts:

  • Lens nucleus – middle aspect of the lens
  • Lens cortex – outer aspect of the lens
  • Lens capsule – the membrane surrounding the lens

Aetiology and Risk Factors

There are many risk factors for developing cataracts. Through a variety of disease processes, risk factors contribute to lens opacification.

The majority of cataracts are associated with age-related changes.

Other risk factors include:

  • Diabetes
  • Steroid use
  • UV exposure
  • Smoking
  • Ocular trauma
  • Genetic predisposition

Common Types of Cataracts

There are 3 main types of cataracts, classified according to the part of the lens affected.

Nuclear cataracts

  • Sclerosis of the lens nucleus
  • Common in old age
  • Symptoms include myopia (short-sightedness) and colours appearing dull
  • Myopia occurs as sclerosis changes the lens refractive index. Patients experiencing this symptom will often say that they previously needed reading glasses, but no longer require them.

 

Cortical cataracts

  • Opacifications of the lens cortex
  • On ophthalmoscopy, the opacifications look like the spokes of a wheel around the edge of the lens.
  • Vision is often unaffected
Cortical cataract
Cortical cataract with wheel spoke appearance 4

 

Posterior subcapsular cataracts

  • Opacifications in the posterior aspect of the lens capsule
  • Typically affect younger patients and individuals taking steroids
  • Patients complain of glare when looking at lights (this can cause issues when driving at night).
  • Progresses more rapidly than other types of cataracts

Clinical Features

Symptoms

  • Progressive blurring of vision
  • Glare when looking at lights
  • Colours appearing dull

Signs

  • Reduced red reflex (elicited by shining a light into the eye)
  • Clouded lens
Mature cataracts with loss of red reflex
Mature cataracts with loss of red reflex 5

 Differential Diagnosis

  • Open-angle glaucoma
  • Macular degeneration

Investigations

Diagnosis is made using history and clinical examination. Slit-lamp examination with dilated pupils can be used to the support diagnosis.


Management

Conservative management

  • Cataracts often begin small with mild symptoms and progress over several years.
  • NICE recommends refraining from surgical management until symptoms inhibit lifestyle.
  • Controlling risk factors such as diabetes, smoking, steroid use and UV exposure may slow down the development of cataracts.

 

Surgical management

Phacoemulsification with an intraocular lens implant is the most common cataract surgery:

  • The opacified lens is broken down using ultrasound and the fragments are aspirated. A new lens is then implanted.
  • Often conducted under local anaesthetic.
  • Prior to surgery, ocular biometry is conducted to measure the corneal curvature and the shape of the eye. It is used to choose a suitable replacement lens.

Complications

If not managed appropriately, cataracts can cause loss of vision.

Surgical complications

  • Posterior capsule opacification is very common. Patients present months to years after cataract surgery complaining that it seems like their cataract is returning. It is treated with a capsulotomy, where lasers are used to make a hole in the capsule to allow light to pass through.
  • Endophthalmitis is an infection of the aqueous and/or vitreous humour. It is a rare, severe complication and can result in visual loss. It is treated with intraocular antibiotic injections.
Posterior capsular opacification
Posterior capsular opacification 6

 Congenital Cataracts

  • Congenital cataracts are present from birth.
  • Associated with infection (typically congenital rubella syndrome) and genetic predisposition.
  • Often diagnosed during the newborn examination due to the absence of a red reflex.
  • Must be urgently referred to ophthalmology, as surgical management may be required in the first 6 weeks of life to prevent amblyopia (permanent visual loss due to the brain neglecting the eye).
Congenital cataracts caused by congenital rubella syndrome
Congenital cataracts caused by congenital rubella syndrome 7

 


Key Points

  • A cataract is an opacification of the lens.
  • It is a common cause of vision loss.
  • Cataracts typically present with a progressive blurring of vision.
  • Surgical management involves phacoemulsification and intraocular lens implant.
  • Surgical complications include posterior capsule thickening and endophthalmitis.
  • Congenital cataracts must be urgently referred to ophthalmology to prevent amblyopia.

References

  1. Oxford handbook of clinical specialties tenth edition. Ophthalmology chapter page 446-447. Published in 2016.
  2. Sunshine Connelly (description by Ruth Lawson). Lens function. [CC BY]. Available from: [LINK].
  3. Johannes Sobotta. Lens anatomy (modified by Jonathan Malcolm). Published 2nd November 2013. Licence: Public Domain. Available from: [LINK].
  4. Imran Kabir Hossain. Cortical cataract. Published 31st May 2017. [CC BY]. Available from: [LINK]
  5. Imran Kabir Hossain. Dense white mature cataract. Published 11th April 2017. [CC BY] . Available from: [LINK].
  6. Rakesh Ahuja. Posterior capsular opacification post-cataract surgery (seen on retro-illumination). Published 10th September 2006. [CC BY] Available from: [LINK].
  7. Congenital cataract. Published 29th May 206. Licence: Public Domain. Available from: [LINK].
  8. The Duke Elder exam of ophthalmology: a comprehensive guide for success. Page 111-117. Published July 2019.
  9. Cataract. Last edited January 2020. Available from: [LINK].

 

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