The nerve supply to the upper limb is an important and complex topic which will inevitably appear in anatomy questions, clinical case scenarios and OSCEs. It is also very relevant to clinical practice.
This article will focus on the five terminal nerve branches of the brachial plexus which supply the upper limb. These arethe musculocutaneous nerve, the axillary nerve, the radial nerve, the median nerve and the ulnar nerve. We will cover their anatomy and function, as well as the clinical features you would expect to find with a nerve injury.
For more information on the muscles of the upper limb, see the Geeky Medics section on upper limb anatomy.
You might also be interested in our Anatomy Flashcard Collection which contains over 2000 anatomy flashcards in addition to advanced features such as spaced repetition. 🫁
Structure of the brachial plexus
The nerve supply to the upper limb is almost entirely supplied by the brachial plexus, a complex intercommunicating network of nerves formed in the neck by spinal nerve roots C5, C6, C7, C8 and T1. The brachial plexus itself in more detail in a separate article here.
Figure 1 summarises the structure and branches of the brachial plexus.
The three cords branch to form the five terminal nerve branches which supply the upper limb:
The lateral cord gives the musculocutaneous nerve and the lateral root of the median nerve
The posterior cord gives the axillary nerve and the radial nerve
The medial cord gives the medial root of the median nerve and the ulnar nerve
The origins of these five nerves are distributed around the third part of the axillary artery.
The musculocutaneous, median and ulnar nerves lie anteriorly and form a characteristic “M” shape around the axillary artery, which is an easy landmark to find on a prosection. When given a diagram or prosection of the brachial plexus to label in exams, look for the “M” shape!
Musculocutaneous nerve (C5/C6/C7)
The lateral cord of brachial plexus, formed from anterior divisions of superior and middle trunks.
The musculocutaneous leaves the axilla by piercing coracobrachialis muscle. It then passes down the arm beneath biceps muscle and ends as the lateral cutaneous nerve of forearm.
It supplies skin of lateral forearm.
The musculocutaneous nerve innervates the anterior compartment of arm (BBC):
Biceps: flexes elbow, supinates forearm
Brachialis: flexes elbow
Coracobrachialis: flexes and adducts the arm at the glenohumeral joint
Musculocutaneous nerve injuries are rare, as the nerve is protected beneath the bulk of the biceps muscle. It may be damaged by stab wounds to the upper arm
Clinical features: Musculocutaneous nerve palsy
Clinical features of musculocutaneous nerve palsy include:
Sensory loss: numbness over lateral forearm
Motor deficit: paralysis of anterior compartment of arm with very weak elbow flexion and weak forearm supination. Absent biceps reflex.
Deformity: wasting of the anterior compartment of the arm. The elbow usually held in extension with forearm pronated.
Axillary nerve (C5/C6)
The posterior cord of brachial plexus formed from posterior division of upper trunk.
The axillary nerve passes beneath the shoulder joint through the quadrangular space with the posterior circumflex humeral artery. It then wraps around the surgical neck of the humerus.
The axillary nerve supplies the “sergeant’s patch” of skin over the lower part of deltoid muscle.
The axillary nerve innervates the following shoulder muscles:
Deltoid: abducts, flexes and extends shoulder
Teres minor: externally rotates shoulder, forms part of rotator cuff which stabilises shoulder joint
Common injuries affecting the axillary nerve include:
Fracture of surgical neck of humerus
Stab wounds to posterior shoulder
Anterior shoulder dislocation
Pressure of crutches on armpits (“crutch palsy”)
Clinical features: Axillary nerve palsy
Clinical features of axillary nerve palsy include:
Sensory loss: numbness over “sergeant’s patch”
Motor deficit: paralysis of deltoid leading to very weak shoulder abduction from 15-90°; weak shoulder flexion and extension. Paralysis of teres minor leading to weak shoulder external rotation.
Deformity: wasting of deltoid muscle, making the bones of the shoulder joint very prominent and obvious. The shoulder may appear adducted and internally rotated.
Radial nerve (C5/C6/C7/C8/T1)
The radial nerve originates from the posterior cord formed from posterior divisions of all three trunks.
The radial nerve passes behind the axillary artery and through the triangular interval to enter the posterior compartment of the arm. It then winds around the spiral groove of the humerus with the profunda brachii artery, between the heads of triceps muscle.
It enters the antecubital fossa in front of the lateral epicondyle of the humerus, between the brachialis and brachioradialis muscles
The radial nerve then branches in the proximal forearm into two terminal branches:
Superficial branch (mainly sensory): descends under brachioradialis muscle to end in the dorsum of the hand
Deep branch (mainly motor): pierces supinator muscle and descends along the posterior interosseous membrane with the posterior interosseous artery
The radial nerve is responsible for the sensory supply to:
Posterior arm and forearm
Lateral ⅔ of dorsum of hand
Proximal dorsal aspect of lateral 3½ fingers (thumb, index, middle and half of ring finger)
The radial nerve supplies the triceps in the posterior compartment of the arm. The triceps extends and adducts shoulder and extends elbow.
The radial nerve innervates the following muscles in the posterior compartment of the forearm:
Brachioradialis: flexes elbow
Anconeus: extends elbow, stabilises elbow joint
Supinator: supinates forearm
Extensor carpi radialis longus and brevis: extend and abduct wrist
Extensor carpi ulnaris: extends and adducts wrist
Extensor digitorum, extensor pollicis longus and brevis, extensor indicis and extensor digiti minimi: extend thumb and fingers at MCPJs and IPJs
Abductor pollicis longus: abducts thumb
Common injuries affecting the radial nerve include:
Fractures of proximal humerus, shaft of humerus or radius
Stab wounds to antecubital fossa, forearm or wrist (this includes blood tests and cannulation)
Pressure of crutches on armpits (“crutch palsy”)
The patient falling asleep with arm hanging over the back of a chair, classically whilst drunk (“Saturday night palsy”)
Somebody else falling asleep with their head lying on the patient’s arm (“honeymoon palsy”)
Excessively tight plaster casts, wristbands or handcuffs
Prolonged tourniquet use on the arm arm, for example during orthopaedic or plastics procedures
Clinical features: Radial nerve palsy
Clinical features of radial nerve palsy include:
Sensory loss: numbness of skin over posterior arm, posterior forearm and radial distribution of dorsum of hand
paralysis of posterior compartment of arm: weak elbow extension
paralysis of posterior compartment of forearm: weak wrist extension, weak thumb extension and finger MCPJ extension
Finger IPJ extension is still possible due to intact nerve supply to the lumbrical muscles of the hand
Absent triceps and supinator reflexes
Deformity: “Wrist drop” deformity at rest and on attempted wrist extension (Figure 2). The patient cannot extend their wrist/fingers, resulting in unopposed wrist flexion. In the classical description of a radial nerve injury, the forearm is also pronated, the fingers are flexed, and the thumb adducted. There may also be wasting of triceps and posterior compartment of forearm.
Median nerve (C5/C6/C7/C8/T1)
The lateral and medial cords of the brachial plexus. The lateral root arises from anterior divisions of superior and middle trunks. The medial rootarises from anterior division of inferior trunk.
The median nerve runs down the arm with the brachial artery. It initially lies lateral to the artery, then crosses over to lie medial to it about halfway down the arm.
The nerve then passes through the medial part of the antecubital fossa between the two heads of pronator teres muscle.
It travels through the anterior forearm between the flexor digitorum superficialis and flexor digitorum profundus muscles and gives three main branches:
Anterior interosseous nerve: descends along the anterior interosseous membrane with anterior interosseous artery
Deep branch: enters hand through the carpal tunnel beneath the flexor retinaculum of the wrist, between flexor carpi radialis and flexor digitorum superficialis tendons
Superficial/palmar cutaneous branch: arises just before the wrist and pierces the palmar carpal ligament to enter the palm over the top of the carpal tunnel – this nerve is therefore not affected by carpal tunnel syndrome
The median nerve does not supply any sensory innervation to the axilla or upper arm.
In the hand, the median nerve supplies:
Skin over thenar eminence
Lateral ⅔ palm of hand
Palmar aspect of lateral 3½ fingers
Dorsal fingertips of lateral 3½ fingers (thumb, index, middle and half of ring finger)
The median nerve does not supply any motor innervation to the axilla or upper arm
The median nerve supplies all muscles of anterior compartment of forearm except flexor carpi ulnaris and the medial two parts of flexor digitorum profundus:
Pronator teres and pronator quadratus: pronate forearm
Flexor carpi radialis: flexes and abducts wrist
Palmaris longus: flexes wrist and tenses palmar aponeurosis
Flexor digitorum superficialis: flexes fingers at PIPJs
Lateral two parts of flexor digitorum profundus: flex index and middle fingers at DIPJs
Flexor pollicis longus: flexes thumb at IPJ
The median nerve also supplies the intrinsic muscles of hand (LOAF muscles):
Lateral two lumbricals: flex MCPJs and extend IPJs of index and middle finger
Opponens pollicis: opposes thumb
Abductor pollicis brevis: abducts thumb
Flexor pollicis brevis: flexes thumb at MCPJ
Common injuries affecting the median nerve include:
Supracondylar fractures of humerus
Stab wounds to antecubital fossa, forearm of wrist (this includes blood tests and cannulation!)
Deep wrist lacerations inflicted during deliberate self-harm
Compression by carpal tunnel syndrome
Clinical features: Median nerve palsy
Clinical features of median nerve palsy include:
Sensory loss: numbness of skin over thenar eminence and median distribution of hand. However, in carpal tunnel syndrome, sensation to the palm is usually preserved due to an intact palmar cutaneous branch.
Paralysis of most of anterior compartment of forearm: weak forearm pronation, wrist flexion and abduction, and weak finger flexion with preservation of DIPJ flexion at ring and little fingers.
Paralysis of thenar eminence: weak pincer grip and overall grip strength, weak thumb opposition.
Deformity: “Hand of benediction” deformity on attempted finger flexion, the patient cannot flex their index or middle fingers, resulting in unopposed extension of those two fingers (Figure 3). They cannot make a fist with all of their fingers. Wasting of anterior compartment of forearm and thenar eminence
Ulnar nerve (C8/T1)
The medial cord of brachial plexus, formed from anterior division of inferior trunk
The ulnar nerve runs down the arm on the medial side of the brachial artery. It passes behind the medial epicondyle of the humerus and enters the forearm between the two heads of flexor carpi ulnaris.
The nerve travels through the anterior compartment of the forearm beneath flexor carpi ulnaris with the ulnar artery. It then enters the palm of the hand through Guyon’s canal
The ulnar nerve does not supply any sensory innervation to the axilla or upper arm.
In the hand, the ulnar nerve supplies:
Skin over hypothenar eminence
Medial ⅓ palm of hand
Palmar aspect of the medial 1½ fingers
Medial ⅓ dorsum of hand
Dorsal aspect of medial 1½ fingers (little finger and half of ring finger)
The ulnar nerve innervates two muscles in the anterior compartment of the forearm:
Flexor carpi ulnaris: flexes and adducts wrist
Medial two parts of flexor digitorum profundus: flex ring and little fingers at DIPJs
In addition, the ulnar nerve innervates most of the intrinsic muscles of the hand (HILA muscles):
Hypothenar eminence: opponens digiti minimi, flexor digiti minimi brevis and abductor digiti minimi: oppose, flex and abduct little finger
Medial two lumbricals: flex MCPJs and extend IPJs of ring and little finger
Adductor pollicis: adducts thumb. adductor pollicis is not part of the thenar eminence and actually lies deep beneath it as a separate structure.
Common injuries affecting the ulnar nerve include:
Supracondylar fractures of humerus
Fractures or soft tissue injuries to medial epicondyle of humerus
Stab wounds to forearm or wrist (this include blood tests and cannulation!)
Compression either at the cubital tunnel in the elbow or at Guyon’s canal in the wrist
Clinical features: Ulnar nerve palsy
Clinical features of ulnar nerve palsy include:
Sensory loss: numbness over hypothenar eminence and ulnar distribution of hand
Paralysis of flexor carpi ulnaris: weak wrist flexion and adduction
Paralysis of medial two parts of flexor digitorum profundus: weak flexion of ring and little finger DIPJs
Paralysis of most of the intrinsic muscles of the hand: weak MCPJ flexion and IPJ extension of ring and little fingers, loss of finger abduction and adduction, loss of opposition of little finger
Deformity: “Claw hand” deformity at rest and on attempted finger extension: the patient cannot extend the IPJs of their ring or little fingers, resulting in fixed flexion of the IPJs and hyperextension of the MCPJs of these two fingers (Figure 4).
The clawed appearance is most pronounced when the nerve is injured at the wrist, for example by compression in Guyon’s canal, as the function of flexor digitorum profundus will be preserved. A claw hand affecting all four fingers is much less common and is usually due to a lesion of the lower part of brachial plexus, such as Klumpke’s palsy. wasting of hypothenar eminence and intrinsic muscles of hand
The sensory supply to the upper limb can be broken down into dermatomes (the area supplied by each spinal nerve root) and peripheral nerve territories. The motor supply to the upper limb can also be broken down into myotomes (the movements which test individual spinal nerve roots) as well as peripheral nerve functions (Figure 5).
The nerve supply to the upper limb is commonly damaged by fractures, penetrating trauma and external compression. Patients with neurological signs following upper limb injuries may appear in OSCE stations.
There are several types of nerve injuries:
Neurapraxia: the nerve is stretched and damaged but not torn
Rupture: the nerve is torn at a point along its length
Axonotmesis: the nerve fibre is partially severed: the axon and myelin sheath are torn but the surrounding epineurium, perineurium and connective tissues are preserved. Natural recovery is possible through axonal regeneration, so these injuries can often be managed conservatively with support and physiotherapy.
Neurotmesis: the nerve fibre is completely severed. There is no prospect of natural recovery, so this type of injury requires surgery to restore function.
Avulsion: the nerve root is torn off the spinal cord at its origin. This can happen in brachial plexus injuries but would not usually cause injury to individual upper limb nerves.
Post-traumatic neuroma: a growth of scar tissue at the site of a previous nerve injury, which leads to compression
For more information on brachial plexus injuries, see the Geeky Medics guide to the brachial plexus.
Dr Chris Jefferies
International Standards for Classification of Spinal Cord Injury 2011 Revised Edition, available from [LINK]
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Sinnatamby CS. Last’s Anatomy, 12th Edition. Published in 2011
Snell RS. Clinical Anatomy by Regions, 9th Edition. Published in 2011