LFTs, U&Es, albumin, coagulation profile: to look for liver and renal disease
Amylase: if pancreatitis is suspected
TFTs: if hypothyroidism is suspected
A chest X-ray is the first-line imaging investigation of choice. This is useful to assess a pleural effusion and estimate its size. A unilateral effusion is typically exudative whereas bilateral effusions are typically transudative.
50ml of pleural fluid can cause costophrenic blunting, but >200ml fluid is needed to be visible on PA film.1
A chest X-ray is also useful to assess for the underlying aetiology of the pleural effusion. Look for consolidation (infection), malignancy, cardiomegaly (cardiac failure) and pleural plaques (asbestos exposure).
Other relevant imaging investigations include:
CT or ultrasound chest: to further characterise pleural effusion and investigate for an underlying cause.
Echocardiogram: to look for signs of heart failure or right heart strain (which may suggest pulmonary embolism).
If a unilateral pleural effusion is thought to be exudative, British Thoracic Society guidelines suggest pleural fluid aspiration (diagnostic) which is usually performed under ultrasound guidance.5
Pleural aspirations are not routinely carried out for bilateral effusions with features suggestive of a transudate.5
Medical thoracoscopy can be used to aid diagnosis in some circumstances. It involves visualising and taking a biopsy of the pleura using a thoracoscope under local anaesthetic.
Pleural fluid should be sent for biochemistry (protein, LDH and glucose), microbiology (gram stain and culture) and cytology. More specialist tests may be needed depending on the likely cause of the pleural effusion.
If pleural fluid protein is 25-35g/L, Light’s criteria are used to distinguish transudative from exudative pleural effusions.
Light’s criteria summary
The fluid is an exudate if one or more of the following criteria are met:6
Pleural fluid protein divided by serum protein is >0.5
Pleural fluid LDH divided by serum LDH is >0.6
Pleural fluid LDH is >⅔ the upper limit of the laboratory normal value for serum LDH
The appearance of the pleural fluid should be noted: purulent fluid suggests infection, bloody fluid may suggest malignancy, pulmonary embolism or trauma.
Fluid pH can be analysed in a blood gas machine if the fluid is not purulent. A fluid pH < 7.3 can indicate malignancy, pleural infection, rheumatoid arthritis, tuberculosis and oesophageal rupture. In parapneumonic effusions, pH <7.2 indicates drainage is needed.5
The main aim of management is to treat the underlying cause of the pleural effusion.
In smaller pleural effusions without symptoms, management may simply involve observation.
Some examples of appropriate medical treatment in exudative or larger transudative effusions are:
Diuretics in heart failure
Antibiotics in infection
Symptomatic patients with larger pleural effusions may benefit from pleural fluid aspiration (therapeutic) or chest drain insertion under ultrasound guidance.
If the pleural effusion reaccumulates, the following options may be considered:
Long term indwelling chest drain
Pleurodesis (by chest drain or medical thoracoscopy)
Some patients may need to have further investigation and management of their effusion by a thoracic surgeon who may carry out video-assisted thoracic surgery (VATS).
Complications vary depending on the cause of the pleural effusion.
Larger pleural effusions may cause increasing respiratory compromise. In parapneumonic effusions, complications may include empyema and sepsis.
Complications, such as pneumothoraces, may relate to pleural procedures carried out during the diagnosis and treatment of a pleural effusion.
Patients with malignancy or pneumonia have a poorer prognosis if a pleural effusion develops.7
A pleural effusion is the presence of an abnormal amount of fluid in the pleural space (a potential space between the visceral and parietal pleura).
Pleural effusions can be transudative (lower protein/LDH) or exudative (higher protein/LDH).
Transudates are commonly due to heart failure and cirrhosis, whereas exudates are commonly caused by infection and malignancy.
Typical symptoms include breathlessness, cough and pleuritic chest pain. Clinical findings may include reduced chest expansion, reduced air entry and a stony dull percussion note on the affected side.
Chest X-ray and pleural aspiration are important investigations to assess and identify the aetiology of a pleural effusion.
On obtaining a pleural fluid sample, pleural fluid appearance and pH should be checked. Fluid should then be sent to biochemistry (for protein and LDH), microbiology (gram stain and culture) and cytology.
The main aim of management is to treat the underlying cause of the effusion.
Smaller transudative effusions can often be managed conservatively with observation. Larger effusions may need therapeutic pleural aspiration.
Complications relate to the underlying cause, but larger pleural effusions can cause respiratory compromise.
Dr Samantha Cockburn
North Devon District Hospital
Dr Chris Jefferies
C. Tidy for Patient.info. Pleural Effusion. Published in 2016. Available from: [LINK].
OpenStax. The lung pleurae. Licence: [CC-BY]. Available from: [LINK].
Clinical Cases. Left-sided pleural effusion. Licence: [CC-BY-SA]. Available from: [LINK].
Sara Nabih. Bilateral pleural effusions. Licence: [CC-BY-SA]. Available from: [LINK].
British Thoracic Society. Investigation of a unilateral pleural effusion in adults: British Thoracic Society pleural disease guideline 2010. Published in 2010. Available from: [LINK].
R. Light et al. Pleural Effusions: The Diagnostic Separation of Transudates and Exudates. Published in 1972. Available from: [LINK].
S. Crane and C. Wearmouth for RCEM Learning. Pleural Effusion. Published in 2011. Available from: [LINK].