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Thyroid pathology quiz
A 28 year old man presents to his GP with a 4cm mobile anterior neck mass. A fine needle aspirate is performed which reveals cells with ‘orphan annie eye’ nuclei and psammoma bodies. What is the most likely diagnosis?
Thyroglossal duct cyst
What is the most common thyroid carcinoma?
Which of the following features is NOT typical for Graves disease?
Hyperplasia of the follicles
Scalloping of the colloid
Irregular shaped follicles
Infiltration of mononuclear cells into retro-orbital connective tissues
Extensive infiltration of the mononuclear cells into the thyroid parenchyma
A 37 year old woman presents to the clinic with 2 days of sudden onset pain in the anterior neck radiating to the jaw. She is otherwise well having reported a full recovery from ‘a cold a week ago’. What findings are NOT consistent with her diagnosis?
Plasma cells aggregating around damaged thyroid follicles
Dense fibrosis of the thyroid gland
Neutrophilic infiltration of the thyroid
Formation of microabscesses
Multinucleated giant cells encapsulating colloid fragments
A 62 year gentleman presents to the clinic with a 5cm painless neck mass as well as diarrhoea for the past 3 months. A biopsy is taken and he is subsequently diagnosed with medullary carcinoma. Which of the following features is consistent with a medullary carcinoma?
Grossly soft and tender mass
Diagnosis of MEN-1 syndrome
Haematologic metastatic spread
High levels of calcitonin
Localised amyloid deposits
Which of the following features is NOT consistent with follicular carcinoma?
Malignant proliferation of follicular cells
Follicular carcinomas are diagnosed via fine needle aspiration
More common in women than men
Commonly have PI-3K/AKT signalling pathway mutations
Uniform cells forming small colloid containing follicles
A 46 year old female presents to preadmission clinic and is found to have a 3cm anterolateral firm painless neck mass along with a minor decrease in calcium serum levels. What is the most likely diagnosis?
Which of the following features are NOT consistent with anaplastic carcinoma?
Large, pleomorphic giant cells
Occasional osteoclast-like multinucleated giant cells
Positive thyroglobulin markers
What thyroid cancer has the worst prognosis? Choose the answer that shows the correct descending order, the first being the cancer with the worst prognosis and the last being the one with the best prognosis.
anaplastic > medullary > follicular > papillary
anaplastic > medullary > papillary > follicular
anaplastic > papillary > medullary > follicular
medullary > anaplastic > papillary > follicular
medullary > anaplastic > follicular > papillary
A 18 year old female presents with a painless 1cm mass in the anterior neck region. A biopsy is taken revealing fluid contained within pseudostratified columnar epithelium. What is the most likely diagnosis?
Thyroglossal duct cyst