Prescribing basics

Top Tips for the Prescribing Safety Assessment (PSA)

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The Prescribing Safety Assessment (PSA) is an online assessment of competency in the safe and effective prescribing of medications, taken by final-year medical students. This article explains how the PSA is structured and provides some useful tips for performing well on the exam.

Prescribing Safety Assessment (PSA) structure

There are 200 marks available over 120 minutes, these marks are split across 8 sections:

  • Prescribing  – 8 x 10 marks
  • Prescription review – 8 x 4 marks
  • Planning management – 8 x 2 marks
  • Providing information – 6 x 2 marks
  • Calculation skills – 8 x 2 marks
  • Adverse drug reactions – 8 x 2 marks
  • Drug monitoring – 8 x 2 marks
  • Data interpretation – 6 x 2 marks

Questions will cover Medicine, Surgery, General Practice, Psychiatry, Paediatrics, Obstetrics & Gynaecology, and Geriatrics.

  • There are 36 seconds per mark; if you are struggling to find an answer within a suitable time frame for the available marks, make a best guess (there is no negative marking) and move on.
  • Get familiar with the BNF (both online and paper versions) and know where to find things as it isn’t always obvious or easy. For example, converting opioid doses is in the palliative care summary, HRT is in the sex hormones summary, and high INR management is in the oral anticoagulants summary.
  • The β€˜Medicines Complete’ BNF is easier to navigate than NICE’s online BNF – you can access this via the PSA website


This section comprises 40% of the available marks. You will be given a clinical scenario and asked to prescribe one drug/ fluid.

Each question has 10 marks available (5 for the drug choice and 5 for the choice of dose/route/frequency).

There are often several correct drug/ dose/ route combinations which will receive full marks. Lower marks are given for suboptimal options.

  • There will be 2 fluid prescribing questions – learn how much fluid a patient is likely to need for resuscitation, rehydration and maintenance, and which fluids to use.
  • For example, patients require ~ 1mmol/kg/day of K+, this should not be infused at a rate >10mmol/hr.

Prescription review

You will be given a clinical scenario and a list of 6-10 drugs the patient is taking, you will need to identify drugs that are contra-indicated (e.g. in renal impairment), causing the clinical picture (e.g. hypokalaemia, confusion, hypotension), or contain a dosing error.

  • The beginning of Appendix 1 in the paper BNF contains several tables of β€˜drugs that cause…’. This saves you from looking up each drug individually when being asked which drug is most likely to cause β€˜x’.
  • Control β€˜F’ is very useful here.
  • Know which drugs are prescribed in MICROgrams (e.g. levothyroxine, digoxin) – these are often prescribed in MILLIgrams to catch you out.
  • The maximum dose of paracetamol is 1g QDS – common dosing errors will include 1g 4hrly or co-prescription of paracetamol and co-codamol.
  • Check the frequency drugs are prescribed at, methotrexate and some doses of bisphosphonates should be prescribed once weekly but may be prescribed daily to catch you out.
  • Learn common enzyme inducers/ inhibitors:

Enzyme inducers: PC BRAS – phenytoin, carbamazepine, barbiturates, rifampicin, alcohol (chronic excess) sulphonylureas. Others: topiramate, St John’s Wort, and smoking.

Enzyme inhibitors: AO DEVICES – allopurinol, omeprazole, disulfiram, erythromycin, valproate, isoniazid, ciprofloxacin, ethanol (acute intoxication), sulphonamides. Others: grapefruit juice, amiodarone, and SSRIs (fluoxetine, sertraline).

Planning management

Here you will be given a clinical scenario and asked to decide which treatment would be most appropriate from several plausible answers.

  • Be aware of the role of non-drug therapies, e.g. TENS, as these may be the most appropriate.

Communicating information

You will need to pick the most appropriate piece of information to give to a patient/carer/healthcare professional about a medication (which is often being started) in a given scenario.

  • Learn the common and serious side-effects and monitoring requirements for: ACEi, antidepressants, anticoagulants, bisphosphonates, HRT, insulin, methotrexate, and statins.
  • Know what to do in the event of a missed contraceptive pill (this varies depending on the type of pill being taken).
  • Take into consideration specific information you are given about a patient when deciding which piece of information is best – e.g. are they of childbearing age?

Calculation skills

You will be asked to make a drug dosage calculation; the question will contain all relevant numerical data as well as distracting data that you will not need. You will be given the units.

  • 1% = 1g in 100mL; 1 in 1000 = 1g in 1000mL
  • You may find it easier to take and use your own calculator instead of the onscreen one.

Adverse drug reactions

You will be asked to determine: the most common or most serious side-effect of a drug, which drug is most likely responsible for an ADR, potential drug interactions, and management of an ADR.

  • Know how to treat anaphylaxis, common overdoses (e.g. paracetamol) and a high INR.
  • Know common/ serious adverse drug reactions e.g.
    • ACEi – cough, hyperkalaemia
    • Amlodipine – oedema
    • Amiodarone – pulmonary fibrosis, thyroid dysfunction
    • Carbamazepine – hyponatraemia
    • Clozapine – agranulocytosis
    • Gliclazide – hypoglycaemia
    • Metformin – lactic acidosis
    • Statins – myalgia
  • More than one drug may list the relevant ADR in its side-effect profile, note how common/rare the side-effect is and pick the drug for which the side-effect has the highest rate of occurrence.

Drug monitoring

You will be given a clinical scenario where a drug (often new) has been prescribed. You will be asked to select the most appropriate monitoring actions.

  • Read carefully whether you are being asked to assess that the treatment is working/ beneficial or whether you are assessing for adverse effects – you will do different tests for each of these.
  • Know what the best timing is for tests e.g. lithium levels.
  • Use a drug’s β€˜monitoring requirements’ and β€˜pre-treatment screening’ sections in the BNF.

Data interpretation

You will be given a clinical scenario and investigation results. You will be expected to determine the most appropriate next step in management (which may be no change at all).

  • Be familiar with different dosing regimens for gentamicin, and how these are monitored.
  • Know how to use the treatment nomogram in paracetamol overdoses.
  • When titrating drugs, for example, thyroxine to get TSH in range, you should usually make the smallest increment change possible.
  • Be aware that abnormal test results don’t always alter the management plan – for example, serum transaminases can be raised by up to 3x the upper limit of normal before statins should be discontinued. [Ref:]

PSA question bank

The Geeky MedicsΒ Prescribing Safety Assessment (PSA) Question BankΒ has been crafted to accurately reflect the style and format of the actual PSA, with all of our questions adhering to official PSA guidelines.

Every question in the PSA question bank has been written and reviewed by doctors, to ensure they deliver excellent educational value.

With our advanced quiz setup, you can generate quizzes based onΒ specialtyΒ andΒ PSA question format.


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