Cranial nerve X is the vagus nerve. The literal translation is “wandering” as it takes a wandering course from the skull to the abdominal cavity. The vagus nerve supplies sensory, special sensory, motor and parasympathetic innervation to structures of the head, neck and thoracoabdominal cavity. First, we will discuss the embryology of the vagus nerve, followed by the structure, function and clinical relevance of this fascinating nerve.

Check out our summary of the cranial nerves here.

You can also check out our Cranial Nerve Anatomy Quiz here.

 

Cranial nerves and cranial foramina diagram

Cranial nerves and cranial foramina diagram 1


Embryology of the vagus nerve

The vagus nerve is associated with two pharyngeal arches – the fourth and sixth.

Fourth pharyngeal arch

  • Bones and soft tissue – thyroid and epiglottic cartilages
  • Muscles – cricothyroideus and soft palate muscles (excluding tensor veli palatini)
  • Nerve – the superior laryngeal branch of the vagus nerve

 

Sixth pharyngeal arch

  • Bones and soft tissue – cricoid, arytenoid, corniculate, cuneiform cartilages
  • Muscles – all intrinsic laryngeal muscles except cricothyroideus
  • Nerve – the recurrent laryngeal branch of the vagus nerve

Having two separate pharyngeal arches develop with independent nervous supply is important, as it allows functional control of phonation and swallowing.


Nuclei of the vagus nerve

The vagus nerve has numerous functions, each derived from different nuclei in the medulla oblongata and pons. We have broken this down simply into the functional classification described below.

Parasympathetic

  • Dorsal motor nucleus

 

Motor

  • Nucleus ambiguus (also parasympathetic to the heart)

 

Special sense

  • Solitary nucleus

 

Sensory (crude touch, pain and temperature)

  • Spinal trigeminal nucleus

Intracranial vagus nerve

Arising from these four nuclei, the fibres of the vagus nerve converge to exit the medulla at the post-olivary sulcus. Superior to this point of exit lies the glossopharyngeal nerve (CN IX); and inferiorly lies the spinal accessory nerve (CN XI).

The vagus nerve then moves inferolaterally with CNs IX and XI to enter the jugular foramen.


Extracranial vagus nerve – head

Upon exiting the jugular foramen, an auricular branch is given off, supplying somatic sensation to the posterior external auditory canal and external ear. This is the only branch of the vagus nerve given to the head.


Extracranial vagus nerve – neck

As the vagus nerve continues to course down the neck, it travels in the carotid sheath, posterior to the common carotid artery and internal jugular vein.

The following branches leave the vagus nerve as it descends the neck (superior to inferior).

Pharyngeal branches

  • Motor innervation to most of the soft palate and pharynx

 

Superior laryngeal nerve

  • Internal branch – sensory innervation to the laryngopharynx and superior larynx (including taste to the epiglottis)
  • External branch – motor innervation to the cricothyroideus muscle

 

Right recurrent laryngeal nerve (branches from the vagus in the neck)

  • Loops under the right subclavian artery and ascends to the larynx
  • Motor innervation to most laryngeal muscles

 

Clinical relevance – vagus nerve examination

The vagus nerve has many functions, but we really only test one of these – the efferent (motor) limb of the cough or gag reflexes. By stimulating the oropharynx with a long cotton tip, the efferent limb of the gag reflex causes the muscles of the pharynx to gag in an attempt to rid this region of the foreign object. During coughing, the vagus nerve provides motor input to roughly the same muscles to constrict the pharynx and allow high velocity, forceful coughing.

Superior laryngeal nerve

Superior laryngeal nerve 3


Extracranial vagus nerve – thorax

Towards the base of the neck, both the left and right vagus nerves take different paths.

Left vagus nerve

  • Passes between the left common carotid artery and the left subclavian artery
  • Then enters the thorax posterior to the sternoclavicular joint
  • Forms the anterior vagal trunk

 

Right vagus nerve

  • Passes anterior to the right subclavian artery
  • Enters the thorax posterior to the sternoclavicular joint
  • Forms the posterior vagal trunk

 

Anterior and posterior vagal trunks

Branches from the vagal trunk contribute to the oesophageal plexus, supplying motor innervation to this muscular structure.

In the thorax, two branches arise from the anterior and posterior vagal trunks.

Left recurrent laryngeal nerve (branches from the anterior vagal trunk in the thorax)

  • Loops under the arch of the aorta and ascends into the larynx
  • Motor innervation to intrinsic laryngeal muscles

 

Cardiac branches

  • Provide parasympathetic and visceral innervation to the heart

 

Clinical relevance – refractory tachycardia

We also know that the vagus nerve supplies the sinoatrial and atrioventricular nodes of the heart with parasympathetic innervation. Patients who lose vagal tone may lose the parasympathetic tone in these regions, allowing uncontrolled sympathetic activity presenting as a refractory tachycardia. While quite rare, keep this in the back of your mind!

 


Extracranial vagus nerve – abdomen

Both the left and right vagal trunk enter the abdomen through the oesophageal hiatus at the vertebral level of T10.

In the abdomen, the vagus nerve terminates as many parasympathetic and sensory branches supplying the oesophagus, stomach, small intestine, and the distal 2/3 of the colon.


Must know

  • CN X is the vagus nerve
  • It originates in the medulla oblongata
  • Its major role is parasympathetic innervation of the viscera
  • The recurrent laryngeal nerve loops under the right subclavian artery and (left) aortic arch
  • It passes through the jugular foramen with CN IX and XI
  • It provides many fibre types, each of which are shown in the table below
General somatic afferentSpecial visceral afferentGeneral visceral afferentGeneral visceral efferentSpecial visceral efferent
Skin around earTaste and sensation to the epiglottisSensory information to body visceraParasympathetic to glands of GI tractMotor innervation to soft palate, pharynx and larynx

References

Reference texts

  • Sinnatamby, C. S. (2011). Last’s Anatomy, International Edition: Regional and Applied. Elsevier Health Sciences.
  • Moore, K. L., Dalley, A. F., & Agur, A. M. (2013). Clinically oriented anatomy. Lippincott Williams & Wilkins.
  • Nolte, J. (2002). The human brain: an introduction to its functional anatomy.
  • Snell, R. S. (2010). Clinical neuroanatomy. Lippincott Williams & Wilkins.

 

Reference images

  1. Patrick J. Lynch, medical illustrator [CC BY 2.5 (https://creativecommons.org/licenses/by/2.5)]. Modified by Dr Lewis Potter.
  2. Henry Vandyke Carter [Public domain]
  3. Jkwchui [CC BY-SA 3.0 (https://creativecommons.org/licenses/by-sa/3.0)]

 

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