Parkinson’s Disease Examination – OSCE Guide

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This guide discusses how to approach performing a focused examination of a patient with Parkinson’s disease in an OSCE setting.

In OSCE scenarios, you may be asked to perform a focused examination to determine the presence (or absence) of a certain condition. It is important to be able to confidently elicit the main diagnostic signs of the condition. In order to do this, you need to be comfortable with the relevant basic system examination (i.e. for a Parkinson’s disease examination you need to be comfortable with performing a full neurological examination).


Background

Parkinsonism is a clinical syndrome characterised by bradykinesia, rigidity, tremor and postural instability.

Idiopathic Parkinson’s disease (PD) is the most common cause of parkinsonism.

Other primary (atypical) Parkinsonian disorders can closely mimic PD, which makes a correct clinical diagnosis challenging. These include progressive supranuclear palsy (PSP), multiple system atrophy (MSA), dementia with Lewy bodies (DLB) and corticobasal syndrome (CBS).

Clinical features of Parkinson’s disease

Typical features

  • Bradykinesia
  • Rigidity
  • Tremor
  • Postural instability

Other features

  • Depression
  • REM-sleep behavioural disorder
  • Autonomic dysfunction (e.g. constipation, urinary frequency)
  • Anosmia
  • Dementia (late feature, typically affecting older patients)

Introduction

Introduce yourself to the patient including your name and role.

Confirm the patient’s name and date of birth.

Briefly explain what the examination will involve using patient-friendly language.

Gain consent to proceed with the examination.

Ask the patient to expose their hands, wrists and elbows (e.g. by rolling up their sleeves or removing a jacket). Observe the patient as they perform these actions as they may provide useful information about the patient’s dexterity and functional independence.

Ask the patient to take a seat.

Wash your hands.

Ask if the patient if they have any pain before proceeding with clinical examination.


General inspection

Parkinson’s disease can be a spot diagnosis– a lot of information can be gained from watching the patient walk into the room and sit down in the chair (we will explore these signs in more detail in the formal assessment of gait).

Perform a brief general inspection of the patient, looking for clinical signs suggestive of Parkinson’s disease:

  • Reduced spontaneous movements and hand gestures
  • Less frequent blinking
  • Hypomimia: a lack of facial expression.
  • Tremor: typically asymmetrical and present at rest, often described as ‘pill-rolling’ in character.
  • Hypophonia: soft, indistinct speech.
  • Abnormal posture: typically stooped in appearance.
  • General inspection
    General inspection

Tremor

Resting tremor

A key and easily observable sign in Parkinson’s disease is a resting tremor. Resting tremors occur when a body part is at complete rest against gravity and cease during active movement.

Typical features of the resting tremor associated with Parkinson’s disease include:

  • Affects the hands: a small tremor in the index finger and thumb is common, causing the typical ‘pill-rolling’ appearance.
  • Asymmetrical (i.e. one limb has more significant symptoms).
  • 4-6 Hz in amplitude
  • The tremor of Parkinson’s disease can also involve the lips, chin and legs.

If there is no obvious tremor on inspection, ask the patient to close their eyes and count back from 20 which should exacerbate a subtle tremor if present.

Action tremor

Although resting tremor is the typical form of tremor associated with PD, patients can also exhibit different types of action tremors. Action tremor can be either kinetic or postural in nature.

Postural tremor

Postural tremor occurs during the maintenance of a position against gravity and worsens during active movement.

Assess for a postural tremor by asking the patient to raise their arms in front of their body and spread their fingers. Postural tremor may emerge after a latency of a few seconds (this is known as a re-emergent tremor).

Kinetic tremor

Kinetic tremor occurs during hand movement (e.g. when writing or during a finger-to-nose movement). Kinetic tremor is also sometimes subdivided into ‘simple kinetic tremor’ in which the tremor remains constant throughout the movement vs ‘intention tremor’ where the kinetic tremor gets worse as the patient approaches a target (e.g. in the finger-to-nose test).

Assess for kinetic tremor by performing a finger-nose test:

1. Position your finger so that the patient has to fully outstretch their arm to reach it.

2. Ask the patient to touch their nose with the tip of their index finger and then touch your fingertip.

3. Ask the patient to continue to do this finger to nose motion as fast as they are able to.

Differential diagnoses

Essential tremor

Typical features:

  • Frequency of 5-10 Hz
  • Kinetic tremor
  • Postural tremor (without latency, unlike PD)
  • Improves with rest and often involves the head and neck

Dystonic tremor

Typical features:

  • Irregular
  • Asymmetrical
  • Kinetic tremor (common)
  • Postural tremor (position-dependent)
  • Variable frequency depending on the position of the affected body part
  • Worsened by specific motor tasks
  • Thumb extension is frequently involved
  • Inspect for evidence of a tremor
    Inspect for evidence of postural tremor

Bradykinesia

Bradykinesia is characterised by slowness in the initiation of voluntary movement with a progressive reduction in speed during repetitive actions, such as voluntary finger-tapping.

Assessment

Bradykinesia can be assessed by asking the patient to perform rapid alternating movements (as big and fast as possible). A patient should be asked to perform 10-20 repetitions for each movement being assessed and the assessment should be performed on one limb at a time. You should demonstrate the movement you want to assess to the patient (you don’t need to assess all of the movements below, just choose one or two).

Finger tapping

Ask the patient to oppose their thumb and forefinger repeatedly, as fast as they can.

Hand grip

Ask the patient to make a fist and open their hand wide repeatedly, as fast as they can.

Pronation/supination

Ask the patient to pronate and supinate their hand repeatedly, as fast as they can.

Toe tap

Ask the patient to keep their heel on the ground and tap their toes against the floor whilst seated as fas as they can.

Interpretation

Whilst observing the patient perform one or several of the above movements observe for the following:

  • Progressive reduction in speed
  • Progressive reduction in amplitude
  • Asymmetry (i.e. struggles to perform rapid movements with left fingers)
  • Slowness in the initiation of movement
  • Assess for dysdiadochokinesia
    Assess for bradykinesia

Tone

Parkinson’s patients typically exhibit increased muscle tone on assessment.

Increased muscle tone can be further subcategorised into spasticity and rigidity. Spasticity is associated with pyramidal tract lesions (e.g. stroke) and rigidity is associated with extrapyramidal tract lesions (e.g. Parkinson’s disease).

Spasticity is “velocity-dependent”, meaning the faster you move the limb, the worse it is. There is typically increased tone in the initial part of the movement which then suddenly reduces past a certain point (known as “clasp knife spasticity”). Spasticity is also typically accompanied by weakness.

Rigidity is “velocity independent” meaning it feels the same if you move the limb rapidly or slowly. There are two main sub-types of rigidity:

  • Cogwheel rigidity involves a tremor superimposed on the hypertonia, resulting in intermittent increases in tone during movement of the limb. This subtype of rigidity is associated with Parkinson’s disease.
  • Lead pipe rigidity involves uniformly increased tone throughout the movement of the muscle. This subtype of rigidity is typically associated with neuroleptic malignant syndrome.

Assessment

Assess tone in the muscle groups of the shoulder, elbow and wrist on each arm, comparing each side as you go:

1. Support the patient’s arm by holding their hand and elbow.

2. Ask the patient to relax and allow you to fully control the movement of their arm.

3. Move the muscle groups of the shoulder (circumduction), elbow (flexion/extension) and wrist (circumduction) through their full range of movements.

4. Feel for abnormalities of tone as you assess each joint (e.g. spasticity, rigidity, cogwheeling, hypotonia).

An activation manoeuvre can accentuate subtle rigidity associated with early Parkinson’s – ask the patient to actively tap their thigh with their contralateral arm whilst you perform the movement.

  • Assess tone
    Assess tone

Gait

Sitting to standing

Ask the patient to stand from their seated position with their arms across their chest to screen for postural instability. Make sure to stand close to the patient so that you are able to intervene if they lose their balance.

Observe gait

Ask the patient to walk to the end of the examination room and then turn and walk back whilst you observe their gait paying attention to:

  • Initiation: typically slow to start walking due to failure of gait ignition and hesitancy.
  • Step length: reduced stride length with short steps is common (shuffling gait). Each step may get progressively smaller as the patient attempts to retain balance (known as festinant gait).
  • Arm swing: reduced arm swing on or both sides (often an early feature of PD).
  • Posture: flexed trunk and neck causing a stooped appearance.
  • Tremor: resting tremor can be observed when the patient is distracted by walking.
  • Turning: impaired balance on turning or hesitancy is common due to postural instability.

Pull test

You can further assess for postural instability by performing the pull test. This test should only be performed by an experienced clinician and ideally with another member of staff present.

Assessment

1. Position yourself behind the patient.

2. Clearly explain the test: “I’m going to give you a quick tug on your shoulders and I’d like you to take two steps backwards to catch your balance. I will be behind you at all times and won’t let you fall.”

3. Perform a test run by tugging gently to see if they are able to maintain their balance (if not, end the assessment here).

4. Tug their shoulders backwards once more, this time with more force: healthy individuals will be able to correct their balance using one or two quick steps.

  • Observe gait
    Observe gait

Other assessments

Ask the patient to write a sentence and draw a spiral to assess for asymmetric progressive micrographia (a typical feature of PD).

Ask the patient to undo and do up their top shirt button (if present) to assess dexterity and speed of movement.


To complete the examination…

Explain to the patient that the examination is now finished.

Thank the patient for their time.

Wash your hands.

Summarise your findings.

Example summary

“Today I performed a neurological examination on a 75-year-old gentleman to assess for clinical features of Parkinson’s disease. On general inspection, the patient demonstrated hypomimia, reduced spontaneous movements in his arms and a soft voice. An asymmetrical tremor was noted in his left hand at rest, involving his forefinger and thumb. A re-emergent postural tremor in his left hand was elicited upon extension of both arms. Asymmetric bradykinesia was detected on the left side with progressive slowness and amplitude of alternating movements. Assessment of tone revealed rigidity in the left wrist, elbow and ankle. Observation of the patient’s gait demonstrated a stooped posture with a reduced arm swing. He had a short stride length and was hesitant when turning. These findings are consistent with the clinical features of parkinsonism.”

“For completeness, I would like to perform the following further assessments and investigations.”

Further assessments and investigations

  • Perform a cerebellar examination: if concerned about cerebellar pathology.
  • Measure lying and standing blood pressure: autonomic abnormalities (e.g. postural hypotension) are a feature of Parkinson’s disease and multiple system atrophy.
  • Assess eye movements: vertical gaze palsy and slow saccadic eye movements are associated with progressive supranuclear palsy (PSP).
  • Perform a cognitive assessment (e.g. MMSE)
  • Analyze the drug chart: medications such as neuroleptics, dopamine blocking antiemetics and sodium valproate can induce secondary parkinsonism.

Reviewer

Professor Oliver Bandmann

Professor of Movement Disorders Neurology


 

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